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Tissue distribution of GLP-1R GLP-1 mediates its effects by binding to its receptor, the GLP-1R, which is a sevenfold transmembrane G-coupled receptor that increases levels of cAMP by activating adenylate cyclase (89, 95, 96)
Li J, Pora BLR, Dong K, Hasjim J
However, native GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) and cleared renally, resulting in a plasma half-life of approximately 23 min [20, 21]
Week 5-6 (or 9-12): If further optimization needed and tolerance permits, increase to 350-400mcg nightly
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