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The heterologous overexpression of Triticum aestivum TaPCS1 in rice increased Cd sensitivity and significantly increased Cd accumulation in shoots but not in roots (Wang et al., CdPCS1 from aquatic macrophyte Ceratophyllum demersum in tobacco ( Nicotiana tabacum), Escherichia coli (Shukla et al., Arabidopsis (Shukla et al., Cucumis sativus ) plants treated with 25 or 50 M Cd, individually or simultaneously with selenium (Se) (Hawrylak-Nowak et al., Metallothioneins Overview Another important metal chelator SH compound and S-donor ligand, metallothioneins (MTs) are products of mRNA translation, characterized as low mass weight (414 kDa) Cys-rich metal-binding proteins, and are widely distributed in both prokaryotic and eukaryotic organisms (Cobbett and Goldsbrough, Metal(loid)-specificity and -chelation mechanisms MTs exhibit their high affinity for both essential and non-essential metals, where MTs can provide thiols for metal chelation in their reduced state

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Experts also propose creating integrated chronic disease clinics to combine weight management with treatments for conditions like diabetes and heart disease, offering a more holistic approach to healthcare