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AR shuttles between the cytoplasm and nucleus and its phosphorylation state has an impact on subcellular localization (PMID: 16282370)

In addition to that, DPP-4 enzyme also deactivates more than 40 physiologically active hormones, neuropeptides, cytokines, and other proteins in vivo through dipeptide cleavage (Mentlein et al., 1993)