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For individuals seeking visible skin benefits or long-term antioxidant support, this format offers a more reliable and bioavailable approach (NIH)

Succinate affects the stability of HIF-1 by inhibiting prolyl hydroxylase domain enzymes (PHDs), which are a class of KG-dependent dioxygenases that can regulate HIF-1 stability in an oxygen-dependent manner, preventing its degradation (117, 118)

These include individuals over 65 years, those with chronic kidney disease, cardiovascular conditions, or immunosuppression

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