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Ferulic acid (FA), the main active component isolated from Angelica sinensis , has been documented to increase the levels of GSH and the expression of GPX in the myocardium by upregulating AMPK2 and activating Nrf2 signaling [41, 165]

However, it was not possible to obtain the initial results again, and this compound was also excluded from clinical trials ( in vitro , so its activity may be due to other mechanisms of action (Maples et al., 2001)

Metformin is co-formulated with members of other medication classes, including SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas

Obesity: Preventing and managing the global epidemic (WHO Technical Report Series No