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Your provider should also evaluate whether gastrointestinal side effects from semaglutide might interfere with levothyroxine absorption (which occurs in the stomach and small intestine)

First, the two medicines in Contrave target the pathways known to regulate mood, energy expenditure, cravings, and pleasure sensation in the brain, said Allison Rhodes, MD, dual-certified obesity medicine and internal medicine physician at The Ohio State University Wexner Medical Center

Beyond achieving more effective glucose control and worthy weight loss, these medications achieved a reduction in rates of major adverse cardiovascular effects, heart failure, kidney disease, and cardiovascular death

The tradeoff is variability in product formulation and the fact that compounded GLP-1s are not FDA-approved brand products