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During 2024 and 2025, the GLP-1 class was increasingly defined by expanded use cases and approvals, with existing drugs gaining indications including cardiovascular risk, sleep apnea and kidney disease

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At a Glance What It Is & Composition Tirzepatide is a single 39-amino-acid synthetic peptide engineered as a dual agonist : one molecule that binds and activates both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor

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