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Characteristic findings in patients with mutations in the HMGCL gene are accumulation of leucine metabolites, 3-hydroxy-3-methylglutaric acid, 3-methylglutaconic acid, 3-methylglutaric acid, and 3-hydroxyisovaleric acid

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These follow-up appointments ensure the medication works effectively and safely

However, some clinicians may prescribe a biweekly dosing schedule off-label as a maintenance strategy once their patients have achieved their weight loss goals