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Al Allawi cautions that for people with established type 2 diabetes and poorly controlled blood sugar, relying solely on diet may delay more effective treatment
Nonetheless, the observation that the D-Ala variant binds with ~8-fold lower affinity to the GLP-1R relative to exendin-4 itself suggests that agonist activity is not determined solely by the stability of conformer 1
For optimal results, injection sites should be rotated at least 0.5 to 1 inch apart to prevent lipohypertrophy, which is the buildup of fatty tissue under the skin
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