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Yes, though rarely
It is believed that the C-terminal is associated with dimerization and contains docking regions for PDE-selective kinases (Essayan, 2001)
Its often used to support immune function, particularly during times of high stress or seasonal illness
Mok RSF, Zhang W, Sheikh TI, Pradeepan K, Fernandes IR, DeJong LC, Benigno G, Hildebrandt MR et al (2022) Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations
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