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The high levels of insulin have been shown to reduce the levels of the Insulin-like growth factor (IGF) binding protein, which can tightly bind to IGFs, resulting in excessive free IGF-1 in cells and tissues
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besides, promoting clinical trial designs to improve the scientific validity and clinical utility of trial results
this drug was shown to reduce CAP values independently of a glucose-lowering effect and to improve lipid, glycemic, and hepatic serum parameters [68]
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