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Dose adjustment should also be considered whenever the patient's weight or lifestyle changes, or when other factors arise that increase susceptibility to hypoglycaemia or hyperglycaemia

Midazolam Nasal Spray: Safety and Effectiveness Profile The safety and efficacy of midazolam nasal spray in patients experiencing seizure clusters were investigated in three phase 3 clinical trials (Acute Rescue Therapy in Epilepsy with Midazolam Intranasal Spray [ARTEMIS-1, ARTEMIS-2, ARTEMIS-EMU]) [49,50,51]

It cannot predict side effects

The shelf life after the bottle has been puncture for the first time is 28 days from that date