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Baseline WOMAC pain score: approximately 6 out of 20 Reduction in active treatment arms: approximately 4.5 points , representing a ~76% decrease from baseline Complete freedom from knee pain at week 68: reported by roughly 1 in 8 patients (12.5%) receiving retatrutide, compared to just 4.2% in the placebo group A 76% reduction in pain scores is extraordinary approaching the range typically seen after total knee replacement surgery

Suspected side effects from any medicine, including unlicensed compounds, should be reported to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk

Patients should discuss with their physicians regarding expected outcomes and timing