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The prevalence of certain alleles such as HLA-Cw12, HLA-DR15, HLA-DQ7 and HLA-DPw9 was significantly higher in patients with isolated ACTH deficiency due to ICI treatments, whereas the presence of HLA-Cw12 and HLA-DR15 was significantly higher in patients who developed ICI-induced hypophysitis (102)
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However, factors such as stress, poor diet, and environmental toxins can deplete glutathione levels in the body
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