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95,96 Pharmacological agents such as GLP-1 RAs mimic endogenous GLP-1 regulatory activities, aiding in T2D management by increasing the incretin effect, postprandial insulin release, increased satiety, and decreased glucagon secretion, thus improving glycemic control
El-Sherbiny IM, El-Baz NM
DAO is an enzyme found in the gut that metabolizes histamine in the GI tract, which can be a significant source of histamine, especially in the presence of SIBO, candida overgrowth and certain pathogenic infections like Kl and ebsiella spp
The mechanism involves activation of AMPK pathways and improvement in mitochondrial function, which addresses metabolic dysfunction at a cellular level that GLP-1 agonists do not directly target
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