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Interstitial Cystitis (IC), alternatively known as Bladder Pain Syndrome (BPS), is a chronic, often debilitating condition characterized by recurring pain or discomfort in the bladder and the surrounding pelvic region
TLRs have three domains as follows: (A) an intracellular Toll-interleukin 1 receptor (TIR) domain, which is essential for downstream signal transduction, (B) a single transmembrane domain, and (3) an extracellular domain (consisting of leucine-rich repeats) that recognizes specific PAMPs (178)
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