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While beneficial for tissue repair, this mechanism theoretically could support tumor growth if malignancy exists
Many patients notice reduced appetite within the first few weeks, followed by consistent weight loss over the next several months
While it remains to be established if specifically inhibiting LC-NE neurons has a similar effect, these findings suggest that systemic GLP-1R agonists activate presynaptic GLP-1Rs on glutamatergic terminals synapsing onto LC-NE neurons, leading to their activation and suppression of food intake
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