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The UK Summary of Product Characteristics (SmPC) for semaglutide does not list hypothyroidism as a contraindication, and clinical trials included participants with thyroid disorders
It provides enough peptide for the higher dose levels without requiring multiple vials per injection
Non-responders exist for both medications
Trial 3 Results at Week 26 in a Trial of RYBELSUS Compared to Sitagliptin 100 mg Once Daily in Adult Patients with Type 2 Diabetes Mellitus in Combination with Metformin or Metformin with Sulfonylurea a The intent-to-treat population includes all randomized patients
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