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GLP-1 analogs targeting midbrain dopamine neurons in the ventral tegmental area have been shown to attenuate high-fat food intake and decrease the excitatory synaptic strength of projections to the nucleus accumbens shell (Wang et al., 2015)
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Similarly, to relieve rheumatoid arthritis (RA), folic acid modified silver nanoparticles (FA-AgNPs) were developed to reduce the secretion of inflammatory cytokines by targeting M1 macrophages for RA treatment [172]
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