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Downregulation of HTR4 ameliorated insulin resistance in the liver
Rather than sitting on the filtering cells of the nephron, the receptor is found mainly in the smooth muscle of the renal vasculature, so much of GLP-1s renal effect is hemodynamic and hormonal rather than a direct action on kidney tubules
323,324,325 Specifically, activation of GLP-1R leads to an increase in cAMP levels, which in turn activates PKA, a widely regulating enzyme of cellular functions, capable of phosphorylating a variety of target proteins, thereby initiating the PKA/CREB signaling pathway
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