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Key Findings: Most common: Nausea (43%), diarrhea (33%), vomiting (21%) Unique to retatrutide: Dysesthesia (20.9% @ 12mg in TRIUMPH-4, 8.8% @ 9mg) Discontinuation rate: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 (general obesity population) compared to semaglutide 6.9%, tirzepatide 6.2% Good news: Most side effects peak during dose escalation and improve significantly after week 16 Management: Slow titration, dietary modifications, and proper timing dramatically reduce severity Understanding the Three Categories of Side Effects 1

Receptor density in cardiovascular and immune tissues is, however, markedly lower than in the pancreas, and the modest physiological increment in GLP-1 produced by DPP-4 inhibition does not appear sufficient to drive the downstream signaling needed for anti-inflammatory, endothelial, or plaque-modifying effects [13], [14], [28]

Try adding lean proteins to your diet like: 2,4 Chicken or turkey: Lower in saturated fat but packed with protein to keep muscles strong

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