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When standard, unformulated glutathione is ingested, the highly acidic environment of the stomach (which has a pH of less than 1.5) and the aggressive digestive enzymes (peptidases) in the small intestine rapidly cleave the tripeptide into its three constituent amino acids
10.1111/j.1432-1033.1994.tb20088.x 64 HanQ.ChenR.YangY.CuiX.GeF.ChenC.et al
The loss of beneficial bacteria means the gut loses its natural ability to regulate the local immune system, setting the stage for widespread structural damage to the intestinal wall
However, these analyses often included smaller trials with shorter follow-up, which may increase heterogeneity and reduce reliability regarding long-term cardiovascular and safety outcomes
