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However, no Phase II or Phase III randomized controlled trials have been published as of 2026, meaning the full safety profile particularly long-term effects, drug interactions, and dose-dependent risks remains incompletely characterized

Some GI symptoms that contribute to dehydration include: Vomiting, which causes fluid loss Diarrhea, which removes both fluid and electrolytes Reduced thirst signals Early fullness that prevents people from drinking enough water These factors do not come from semaglutide directly changing urine odor

The steadiness is part of why so many users report the effect as smooth rather than jarring

Not everyone is a candidate for semaglutide treatment