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31 In a trial evaluating semaglutide for weight loss, the incidence of acute pancreatitis was still low (3 of 1,306 participants) despite a higher dose and more significant weight loss, but none of the 655 individuals in the placebo group developed pancreatitis
It is a synthetic analogue of human GLP-1, modified to resist enzymatic degradation and extend its duration of action
Patients may not volunteer these symptoms unless asked directly
These medications fall under a class known as glucagon-like-peptide-1 receptor agonists also known as GLP-1s
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