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in 12 HFpEF patients who underwent bariatric surgery, an improvement in Minnesota Living With Heart Failure score (p=0.018), a lowering in LV myocardial mass (p=0.001) and a reduction in NYHA functional class of HF were observed at 3 and 6 months after surgery
The effect of weight loss on periods is therefore not universally negative and is highly context-dependent
Semaglutide does not cross the blood-brain barrier, yet it directly targets the brainstem, septal nucleus, and hypothalamus
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