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Avoid alkaline solvents and buffers: NAD+ is comparatively stable in acid but hydrolyses in base at both the nicotinamide-ribose glycosidic bond and the pyrophosphate linkage, and NADH behaves in the opposite direction
Bioanal Chem
In humans, NMN doses as high as 1,200mg/day and daily NR doses up to 2,000mg have been illustrated as safe for use over a six-week period.4 31 So, a daily dose of either NMN or NR or a combination of the two up to 1,200mg should be perfectly safe for most people
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