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In concordance with the above, weight loss of a magnitude obtainable with bariatric surgery, or with newer agents such as semaglutide (Wilding et al., 2021) or the GIP/GLP-1 dual receptor agonist tirzepatide (Rosenstock et al., 2021
Semaglutide lowers circulating ghrelin levels, which typically drive hunger, and, by reducing calorie intake and body fat, it also alters leptin dynamics and leptin sensitivity
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