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GLP-1 receptor agonists, SGLT2 inhibitors and DPP-4 inhibitors GLP-1 receptor agonists, sodium glucose co-transporter-2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of MACE compared to placebo
These results indicate that downregulation of the PPARa pathway reduces FABP1 expression, leading to alterations in GPX4 and ACSL4 levels that contribute to HMC ferroptosis and IgAN pathogenesis [161]
Additionally, GLP-1 receptor activation suppresses glucagon secretion from pancreatic alpha cells, reducing hepatic glucose production
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