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Single receptor agonists, liraglutide and semaglutide, were not shown to measurably cross the BBB, implying that these GLP-1 receptor agonists may influence brain function indirectly and act at brain regions outside the BBB [21]
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The intramuscular doses give you faster but shorter-acting peaks
Recently, the European Medicines Agency's Pharmacovigilance Risk Assessment Committee (PRAC) reviewed GLP-1 receptor agonists and found no evidence of increased risk of suicidal thoughts or self-harm, though monitoring continues
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