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In a recent review (2018) by the famous Cochrane Institute, it was reported that studies which had been published on this topic only provided very low-quality evidence that oral B12 is as efficacious as intramuscular B12

Metabolic research focus: Examined in obese rodent studies for changes in weight gain patterns, fat oxidation, and markers associated with lipolysis and lipogenesis

Muscle mass preservation Helps prevent catabolic breakdown during caloric restriction or high-intensity training cycles

For a vitamin B12 injection to have an effect, several things must be considered, including the individuals metabolism and how frequently the injections are given