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The role of site rotation Injecting repeatedly in the same area can irritate tissue, causing both bruising and small lumps (lipohypertrophy) that reduce absorption
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Afterward, they are stored in the gallbladder, released into the intestinal lumen after a meal, and further metabolized by the gut microbiota into secondary bile acids
This direct vascular effect can contribute to blood pressure improvement independent of weight loss alone, though the magnitude varies by individual genetic factors
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