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The PPP1R3B rs4240624 variant is linked to liver glycogenosis and increased alanine aminotransferase (ALT) levels 50
Safety Considerations and Who Should Start Tirzepatide at 12.5 mg The 12.5 mg starting dose is generally appropriate for adults with type 2 diabetes or obesity who have no contraindications
These could signal hypoglycemia, thyroid dysfunction, or infectionnone of which are typical semaglutide side effects
It also compounds the risk of functional decline and bone density loss, which is the opposite of what a longevity-focused patient is working toward
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