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Reduced amyloid- accumulation and tau hyperphosphorylation, demonstrated repeatedly in animal models

Knockdown of GLP-1 Receptors in Vagal Afferents Affects Normal Food Intake and Glycemia

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(They studied participants who did not have diabetes because the disease introduces more confounding variables.) The researchers suspected that people with the PAM variant would have lower levels of GLP-1 in their blood, perhaps because the unamidated form would be less stable