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Agents such as orforglipron, a first-inclass, non-peptidyl GLP-1 RA, demonstrate that small-molecule scaffolds can achieve clinically meaningful glycemic and weight-lowering efficacy with once-daily oral administration [74]
This is why some individuals feel like they are doing everything right but still struggle to see results
However, the symptomatic overlap means that patients with IBS may find it challenging to distinguish between their baseline condition and medication-related side effects
Similarly, the FDA's reviews of the clinical trials, including large outcome studies and observational studies did not find an association between use of GLP-1 RAs and the occurrence of suicidal thoughts or actions
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