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PMID: 16547503

10.1038/s41420-024-02278-8 40 CheD.XiaoY.ZhangX.ZhuK.ChenW.YouG.et al (2025)

Potential benefits for the gut include: Reducing intestinal inflammation in IBD and colitis Modulating immune response to prevent overactivation Decreasing harmful bacterial overgrowth and supporting a healthier gut microbiome Enhancing epithelial barrier function to prevent leaky gut How it works: KPV helps regulate cytokine production, balancing the immune systems activity so it calms inflammation without shutting down natural defenses

This acidifies the tissue microenvironment, which can suppress T cell function and cytotoxicity, further impairing the antiviral immune response (65)