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Long-Acting GLP-1 RAs Exenatide (Bydureon) In 1987, scientists discovered that GLP-1 promotes insulin secretion, and five years later, an entero-insulin analogue, Exendin-4, which is 53% homologous to GLP-1, was isolated from the saliva of the Mexican giant lizard, later known as exenatide, which has GLP-1 receptor agonist activity and a half-life of 2.4 hours
However, they can be easily corrected and prevented through supplements and through B12 shots
De Gregorio C, Marini H, Alibrandi A, Di Benedetto A, Bitto A, Adamo EB, et al
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