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In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability

For researchers making decisions today, the calculus is relatively straightforward

Weight loss can help mitigate these complications, but losing weight through diet and exercise alone can prove challenging

No randomized controlled trials in healthy humans with orthopedic injuries have been completed