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19 Lofton H, Ard JD, Hunt RR, Knight MG

In addition to components of the PDHc itself, mutations in the gene (PDP1) encoding one of the catalytic subunits of the major PDH phosphatase and mutations in the gene (PDHX) that encodes a E3 subunit binding protein, have been shown to be associated with PDH deficiency syndromes

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) This Long R3 variant includes a 13-amino-acid extension and an arginine substitution at position 3

A network meta-analysis found that adverse events were more frequent with retatrutide (relative risk 4.10) compared to tirzepatide (relative risk 2.78)