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rather, it provides one possible framework in which such effects may be embedded within a broader multi-level process that could, in some individuals or contexts, be shaped more strongly by central valuation and motivational mechanisms (Figure 2)

GLP-1RA medications are the first pharmacotherapy for obesity with demonstrable cardiovascular benefits and ASCVD risk reduction

They also highlight a recurring pattern in peptide drug development: early safety signals, particularly those observed at supraphysiologic exposure levels or in non-human models, have frequently led to premature abandonment of otherwise biologically compelling targets

Global Burden of Disease Attributable to Hypertension