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Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
Rare side effects are hypoglycemia, pancreatitis, diabetic retinopathy, gall bladder problems, gastroparesis (due to slowed gastric emptying), and increased risk of aspiration during sedation and anesthesia
Bupropion may also be better for patients with a history of opioid use disorder or who use opioids chronically since Contrave should be avoided for these patients
Reduced Stress and Anxiety: Balance cortisol levels to promote a sense of calm
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