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Common symptoms include anemia, fatigue, weakness, lightheadedness, pale skin, and neurological issues such as tingling or numbness in the hands and feet, muscle weakness, memory problems, poor appetite, and mood changes
The severity of symptoms does not always correlate with serum B12 levels, and some patients with borderline-low results may experience significant neurological impairment
CJC-1295 without DAC (also called Modified GRF 1-29) has a half-life of approximately 30 minutes, while CJC-1295 with DAC binds to serum albumin via a maleimide linker and extends the half-life to roughly 68 days, allowing weekly rather than daily dosing in research models
PMID 16687029
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