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After 72 weeks of treatment: 5 mg dose: 15.0% mean body weight reduction 10 mg dose: 19.5% mean body weight reduction 15 mg dose: 20.9% mean body weight reduction Placebo: 3.1% mean body weight reduction Among participants receiving 15 mg, approximately 57% achieved at least 20% weight loss
Notably, many GHK-Cu-regulated genes demonstrate age-dependent dysregulation, with the peptide effectively reversing age-associated expression changes toward more youthful patterns
Ann Thorac Surg 108(2):370-376, 2019
Food & Drug Administration: Donnelly, B
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