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In 3Tg-AD treated with DA-JC4, the ability of recognize new object and spatial working memory was improved, hippocampal A and tau pathology were alleviated, and hippocampal synaptic plasticity also was improved as well as levels of PSD95 and SYP were increased (235)

As such, reuterin plays an important role in the maintenance of a healthy gut microbiome, thereby supporting optimal intestinal permeability

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Subsequent trials, including SUSTAIN-6, Harmony Outcomes, and AMPLITUDE-O, reported similar MACE reductions but without a mortality benefit [15,16,17]