Both medicines should be stopped in women who are planning pregnancy, since semaglutide is not recommended during conception or pregnancy
Abbreviations and Acronyms ARNI = angiotensin receptor-neprilysin inhibition CMR = cardiac magnetic resonance CRT = cardiac resynchronization therapy HFimpEF = heart failure with improved ejection fraction HFmrEF = heart failure with mildly reduced ejection fraction HFpEF = heart failure with preserved ejection fraction HFrEF = heart failure with reduced ejection fraction ICD = implantable cardioverter-defibrillator LVAD = left ventricular assist device NICM = nonischemic cardiomyopathy SGLT2i = sodium glucose co-transporter 2 inhibitor SMR = secondary mitral regurgitation Funding Support and Author Disclosures Dr DeFilippis serves on a clinical trial committee for Abiomed and has had speaker engagements with AstraZeneca

A provider-guided semaglutide program may help eligible patients: reduce appetite improve fullness after meals support steady weight loss over time improve adherence to a nutrition plan build better long-term habits with medical oversight The best results typically happen when medication is paired with nutrition guidance, activity, follow-up care, and realistic lifestyle changes
Pezzola S, Antonini G, Geroni C, Beria I, Colombo M, Broggini M, Mongelli N, Leboffe L, MacArthur R, Mozzi AF, Federici G, Caccuri AM: Role of glutathione transferases in the mechanism of brostallicin activation