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For those who have been on medication long-term and notice a slowdown, a semaglutide plateau or tirzepatide losing effectiveness can occur
Research from Eli Lilly on tirzepatide is ongoing, with numerous clinical trials examining its broader implications for diabetes care and weight management
Any uninsured patient considering long-term GLP-1 therapy should undergo baseline metabolic and renal assessment
Since it is not yet approved, there is no official guidance for long-term dosing or real-world use
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