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However, laboratory evidence doesnt automatically translate to what happens in humans
Like other incretin-based therapies, it requires a stepwise titration protocol to balance effectiveness with safety, particularly gastrointestinal side effects that tend to appear at higher doses
The dual action of Tirzepatide effectively reduces caloric intake while improving glucose metabolism, which explains why the SURMOUNT-1 trial data showed up to a 22.5% mean weight reduction at the 72-week mark
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