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GH works in pulses, not as a constant background level
(6) I Ct, Y Sakarya, N Kirichenko, et al (2016) Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction Canadian Journal of Physiology & Pharmacology, 2016 Oct 19, Volume 95 (Issue 2), Pages 206214
Lancet 394 , 131138 (2019)
So, in this case, the water retention can be an indirect side effect of the peptide's primary effect on appetite
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