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Mechanistically, the NF-kB and cytokine effects should theoretically help, but lupus pathogenesis involves pathways (particularly type I interferon and complement activation) that may not be as responsive to GLP-1 signaling
Because of this, its recommended that anyone starting treatment be screened for existing mental health conditions and closely monitored for changes in mood or behavior over time
The potential for semaglutide to influence testosterone levels also extends to its impact on insulin sensitivity and glycemic control
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