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Furthermore, ZEB1 expression was significantly upregulated in stromal cells resistant to chemotherapy but appeared to be more susceptible to ferroptosis induced by statin treatment or GPX4 inhibition [7]

Conclusion In this large real-world study emulating a target trial, initiation of GLP-1 RA therapy among patients with T2DM was associated with a modestly higher incidence of psoriasis and lower incidences of pemphigus and bullous pemphigoid compared with DPP-4i therapy, while no increased risk was observed for most other autoimmune or inflammatory skin diseases

While most cancers are typically treated with radiotherapy, ferroptosis may provide a new avenue for such treatment

Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S (2009) Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice