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To better understand the cellular uptake mechanisms of targeted nanocarriers we investigated the effects of free ligands, metabolic and endocytic inhibitors, and the modification of brain endothelial surface charge

Mechanistically, the mitogenic effect promoted by HGF in SVZ cells is dependent on the activation of the ERK pathway ( Previous reports in the context of SCI recovery reported a positive effect of HGF in the promotion of grafted NSC differentiation and synapse formation between new neurons and the descending cortico-spinal fibers ( Neural stem cell differentiation into astrocytes and, at a lower extent, into new neurons is regulated by some factors such as bone marrow proteins (BMPs), whose expression is upregulated in the injury lesion after SCI ( in vitro similarly to BMSCs and in a dose-dependent fashion

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